HPC as a Service: A naive model

Applications like Big Data, Machine Learning, Deep Learning and even other Engineering and Scientific research requires a lot of computing power; making High-Performance Computing (HPC) an important field. But access to Supercomputers is out of range from the majority. Nowadays Supercomputers are actually clusters of computers usually made-up of commodity hardware. Such clusters are called Beowulf Clusters. The history of which goes back to 1994 when NASA built a Supercomputer by creating a cluster of commodity hardware. In recent times a lot of effort has been done in making HPC Clusters of even single board computers (SBCs). Although the creation of clusters of commodity hardware is possible but is a cumbersome task. Moreover, the maintenance of such systems is also difficult and requires special expertise and time. The concept of cloud is to provide on-demand resources that can be services, platform or even infrastructure and this is done by sharing a big resource pool. Cloud computing has resolved problems like maintenance of hardware and requirement of having expertise in networking etc. An effort is made of bringing concepts from cloud computing to HPC in order to get benefits of cloud. The main target is to create a system which can develop a capability of providing computing power as a service which to further be referred to as Supercomputer as a service. A prototype was made using Raspberry Pi (RPi) 3B and 3B+ Single Board Computers. The reason for using RPi boards was increasing popularity of ARM processors in the field of HPCComment: 2019 8th International Conference on Information and Communication Technologies (ICICT), Karachi, Pakistan, 201

Quality of Hypospadias Surgery in a High Volume Hospital: Review of Short to Medium-Term Outcomes after Snodgrass Hypospadias Repair

OBJECTIVES The study aimed to review short-term and medium-term outcomes of Snodgrass repair from one-year to two-year follow-up. METHODOLOGY It’s a retrospective review of 114 patients (secondary data) with distal penile hypospadias without curvature who underwent Snodgrass repair performed by a single surgeon in the department of Urology, Lady Reading Hospital Peshawar from March 2021 to March 2022. Hypospadias objective score Evaluation (HOSE) was used for functional and cosmetic outcomes. RESULTSThe mean age at the time of presentation for surgery was 3 years. The mean documented follow-up was 13 months (2-23 months). 51% (58) of patients presented with coronal hypospadias, followed by sub-coronal, distal and glanular hypospadias. Overall complication rate was 10%. Three patients developed a total breakdown of their wounds that needed further staged procedures. Meatal stenosis was noted in three patients requiring meatal dilatation, and another two came back with non-obliterative strictures. One had gentle dilatation, and the other underwent an optical urethrotomy. The rest of the four patients developed urethrocutanoeus fistulae (UCF), ultimately getting repaired 6 months postoperatively. Good cosmetic and functional results were achieved in 93% of cases (HOSE score of 14 or above). CONCLUSION This study shows that Snodgrass repair is the best option for mainly correcting distal penile and midshaft hypospadias and has an acceptably low complication rate with better short to medium-term outcomes

Molecular docking unveils prospective inhibitors for the SARS-COV-2 main protease

The recent emergence of a novel coronavirus strain (SARS-CoV-2) has stimulated global efforts to identify potential drugs that target proteins expressed by this novel coronavirus. Among these, the main protease of SARS-CoV-2 (3CL-protease (3CLPro), also known as (MPro) is one of the best choices for the scientists to target. 3CLPro is involved in the processing of polyproteins into mature non-structural viral proteins. An X-ray crystallographic structure (PDB ID 6LU7) of this protein was obtained from the PDB database. ChemDiv libraries of ~80,000 antiviral and ~13,000 coronavirus-targeting molecules were screened against the 3D structure of 3CLPro of SARS-CoV-2. We have identified a panel of molecules that showed an activity and potentially block the active site of the SARS-CoV-2 main protease. These molecules can be investigated further to develop effective virus-inhibiting molecules to treat this highly distressing disease, causing extreme unrest across the globe